Your web browser is out of date

For the best experience, please upgrade. Learn more

Anti-Inflammatory Action of Geranium Essential Oil

Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil Authors: Naho Maruyama, Hiroko Ishibashi, Weimin Hu, Shinichiro Morofuji, Shigeharu Inouye, Hideyo Yamaguchi, and Shigeru Abe Abstract: To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and [...]

Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil

Authors: Naho Maruyama, Hiroko Ishibashi, Weimin Hu, Shinichiro Morofuji, Shigeharu Inouye, Hideyo Yamaguchi, and Shigeru Abe

Abstract:

To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 ?L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.

Introduction:

Aromatherapy is one of the alternative medicines using essential oils and has long been used as an herbal medicine. Recently essential oils have been empirically used worldwide for clinical conditions including various kinds of inflammatory diseases, such as allergy, rheumatism, and arthritis. These activities have mainly been recognized through clinical experience, but there has been relatively little evidence about the pharmacological actions of these oils.
Several investigators have suggested that tea tree [1, 2] and lavender [3] oils suppressed allergic symptoms through the suppression of histamine release [4, 5] and cytokine production [6] in vitro and in vivo. Several essential oils such as eucalyptus [7] and lavender [8] oils inhibited carrageenan-induced paw edema. Moreover, in human, skin application of tea tree oil was reported to suppress the edema induced by intradermal injection of histamine [9]. However, the chronic effects of essential oils using inflammatory mice model have hardly been investigated.

Previously we reported that the essential oils such as geranium oil suppressed the adherence response of neutrophils in vitro [10], and that the intraperitoneal administration of geranium oil lowered neutrophil recruitment into the peritoneal cavity induced by injection of a chemotactic agent, casein in vivo [11]. We also reported that both intraperitoneal and cutaneous applications of the oil suppressed cellular inflammation and neutrophil accumulation to the inflammatory sites which were induced by curdlan, a linear (1 ? 3)-?-D-glucan known as an immunostimulating substance in fungi [12]. These results suggested the possibility that geranium oil might effectively suppress symptoms in inflammatory disease associated with neutrophil activities.

In the present study, we investigated the effects of geranium oil on carrageenan-induced foot edema and collagen-induced arthritis, which are models for acute and chronic inflammation accompanied by neutrophil accumulation.

Conclusion:

It was noted that 5 ?L of geranium oil suppressed the foot swelling during and after the oil injection period, suggesting a long-lasting effect of this oil. Preliminary study showed that indomethacin inhibited the swelling only during its administration, and 1 week after completion of the injection the feet gradually swelled (data not shown). This indicates that repetitive administration of the oil may elicit a long-lasting effect.

In aromatherapy, several essential oils can be applied as a help in therapeutic treatments for inflammatory symptoms with lesional neutrophil accumulation, such as arthritis, aphthous stomatitis, lesional bacterial or fungal infections. Their effectiveness is postulated clinically, but little experimental evidence has been obtained. Our two results give basic evidence about the activity of geranium oil for both acute and chronic inflammatory disorders.

Share Share

Discover how to enhance your life with Mother Nature’s remedies

We’ve got the blueprints for health, beauty, spirituality, and more..

Start Quiz

In Eternal Memory of  Eric Cech, Ananda’s Founder 

    In Eternal Memory of Eric Cech, Ananda’s Founder “The best business model I can hope for is one that will run out of business.” – Eric Cech Eric’s business mindset was otherworldly. He admitted in casual conversation to his wife Anita one day: “The best business model I can hope for is one that […]

Thank You for Your Incredible Support

It Comes with the Greatest Pleasure To let You Know… that…Because of YOU Ananda has Managed to Survive one of the Most Uncertain Times of its Tenure  ~ We can not thank you enough for your enormous patience, understanding and support. From your incoming calls, comments on social media, direct messages across various channels, emails […]

CUSTOMER HEARTFELT RESPONSES

Here are a small fraction of the heartfelt responses we have received following the notice of our business closure and liquidation sale. We offer all of you a deserved shout out for being the improbable,  most essential, significant, factor in creating the Dream you are voicing to us: Hope for a Sustainable Future and Provider […]

Thank You For your Support

Thank You For your Support Since 2004 The Ananda Apothecary is Closing Business   SAD BUT TRUE As previously disclosed, The Ananda Apothecary has been greatly affected by to the global health situation. Bottom line is, we were increasing growing slim on product with no resupply any time soon. We are unable to get goods […]

Spring Cleaning Special

* SPRING CLEANING SPECIAL * *OFFERS VALID APRIL 24 – MAY 2, OR UNTIL SUPPLIES LAST. SOME RESTRICTIONS APPLY. WE’RE GIVING OILS AWAY Get Yours Today! WITH ANY PURCHASE THAT FITS YOUR BUDGET GET UP TO THREE OF YOUR ALL TIME FAVORITE OILS FREE *We have limited supplies due to overseas shipping restrictions. Order now while supplies last. ALSO […]

Reduce Anxiety with These Essential Oils Daily

There’s tons of research on Lavender helping sleep and anxiety (see this post) but what does the science say about other daily-use oils. For those who’d love to try something different, there’s a great many other essential oils have been shown to have anxiety and depression-reducing properties in laboratory studies.* Sweet Orange has been the […]